given that BPA has such a short half-life in the blood? How does one tack down an etiologic relationship for an adult cancer that may be due to an exposure in childhood or adolescence with a chemical that disappears and can no longer be detected in the adult?
following are the guidelines
1.WHAT is the research question/hypothesis?
2. WHY is it important?
– Opportunity to provide information on incidence, mortality, disparity, survivorship, etc… – Individual burden vs. population burden
– Quick summary of descriptive statistics from mid-term assignment
3. WHAT has been done/observed so far in support (or not) of the hypothesis? – Biology (if needed but brief)
– Animal/in vivo studies
– Population-based studies
4. CLEARLY STATE the research gap(s)
– Is there a controversial aspect to this question or inconsistency of research results to date?
5. DESCRIBE how you propose to address this research gap using epidemiologic study(ies) that could be implemented
– PICO -Population/Problem, Intervention/Exposure, Comparison, Outcome. – Also can add design, innovation, limitations, strength, challenges
– More than more research is needed…
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