What is the first-line therapy for osteoarthritis and the mechanism of action? (Let this paragraph discuss current evidenced based pharmacological mech of action at cellular level. It must be an academic and scientific not literal.)

Sally is a 50-year-old female who has been a jogger for several years. She has recently been diagnosed with osteoarthritis. She has been taking Ibuprofen for 3 months but states that it does not help and hurts her stomach. The health care provider prescribes celecoxib (Celebrex) 100 mg orally twice a day.
1. What is the first-line therapy for osteoarthritis and the mechanism of action? (Let this paragraph discuss current evidenced based pharmacological mech of action at cellular level. It must be an academic and scientific not literal.)
2. Sally expresses concern about all the recent news about heart problems and celecoxib (Celebrex). What information should be included in a teaching plan to help her understand about taking celecoxib and the benefits and risks? (Teaching plan must include dosage, drug interactions, contraindications in specific groups of patients, systemic adverse effects, effect of celecoxib on the heart, benefits and risks)
3. Ibuprofen and celecoxib are both nonsteroidal anti-inflammatory drugs. Explain how they are similar and different? (There must be a separate paragraph for similarity and the other for differences)
Submission Instructions:
Your initial post should be at least 500 words, formatted and cited in current APA -7 style with support from at least 5 academic sources.
All replies must be constructive and use academic journal literature only less than 5 years old (2016 till 2022).
No website, blog, online newspaper, magazine, or editorial must be used as a source of reference.
Clear, precise academic grammar must be used with APA-7 style paraphrasing, conjectures and summary.
No introduction or conclusion subheadings (refer to your current APA manual).
The faculty is very strict on cross checking/matching students post with their references. Every sentence will be matched with your references.
Your work is scored on fluency, lack of grammatical errors and addressing the core issues in the questions.
Use your paragraphs wisely to hit those points home or else you lose points.
Please comply with above instructions.

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