Agnes is 45 years old when she notices that her hands shake (tremor) when she is performing everyday tasks like signing contracts at her law firm. Her friends and family also notice that she is moving slower than usual, and that she shuffles when she walks. After consulting with a neurologist, Agnes is diagnosed with Early-Onset Parkinsons disease.
What is Early-Onset Parkinsons disease? How is the disease different from Parkinsons disease?
What is the neurotransmitter affected by this disorder? What is this neurotransmitters role? How does the decrease in the concentration of this neurotransmitter explain Agnes symptoms?
What is the most common treatment for this disorder? What is the mechanism of action of the treatment?
Agnes neurologist refers her to a geneticist who later determines that she carries an autosomal dominant mutation in the SNCA gene associated with Early-Onset Parkinsons disease. Find a reliable source related to the relationship between the SNCA gene and Early-Onset Parkinsons Disease. Summarize the information you obtain. Based on your research, would you advise her three children to have genetic testing performed to determine if they also carry the disease mutation? Why or why not? Include the appropriate reference and citation for the source you consulted.
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