If you were to design a medication for high blood pressure, how would you design it?

If you were to design a medication for high blood pressure, how would you design it? What system(s) would you target? How would this drug work on a biochemical level (what physiological pathways would it affect)? Could it have multiple targets? What would be the potential side effects?
(Be creative this drug could target somewhere other than the Cardiac vascular system. Also, do not just list drugs that already exist by name.)

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