Do you think large muscle mass exercises (e.g. squats) need to be prescribed at the start of a program, before more isolated muscle group exercises (e.g. leg extensions, bicep curls) to maximize hypertrophic gains?

Do you think large muscle mass exercises (e.g. squats) need to be prescribed at the start of a program, before more isolated muscle group exercises (e.g. leg extensions, bicep curls) to maximize hypertrophic gains? i.e. will I get better gains for biceps hypertrophy by prescribing squats at the start of a workout? Explain your answer with appropriate scientific evidence, showing understanding of the mechanisms for hypertrophy, and the relevance of an acute hormonal response with regards to the training stimulus.

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